General description

A cell-permeable isoquinolinone compound that acts as an NAD⁺-binding site-targeting, PARP-2-selective inhibitor (IC₅₀ against murine PARP-2 and bovine PARP-1 = 0.15 and 8.0 µM, respectively). Reported to preferentially inhibit PARP activity in nuclear extracts derived from PARP-1^-/- over PARP-1^+/+ murine fibroblasts (by 80% and 15%, respectively, at 10 µM), while exhibiting little effect against tankyrase-1-dependent mitotic spindle formation in HeLa cells even at concentrations as high as 100 µM.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Moroni, F., et al. 2009. Br. J. Pharmacol.157, 854.Pellicciari, R., et al. 2008. ChemMedChem3, 914.

Soluble in DMSO ( mg/ml), aliquot & store at -20*C; stable for 6 months.

Packaging

5 mg in Glass bottle

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)